Evolutionary Reshaping of Fungal Mating Pathway Scaffold Proteins
نویسندگان
چکیده
منابع مشابه
Evolutionary Reshaping of Fungal Mating Pathway Scaffold Proteins
Scaffold proteins play central roles in the function of many signaling pathways. Among the best-studied examples are the Ste5 and Far1 proteins of the yeast Saccharomyces cerevisiae. These proteins contain three conserved modules, the RING and PH domains, characteristic of some ubiquitin-ligating enzymes, and a vWA domain implicated in protein-protein interactions. In yeast, Ste5p regulates the...
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Scaffold proteins organize signaling proteins into pathways and are often viewed as passive assembly platforms. We found that the Ste5 scaffold has a more active role in the yeast mating pathway: A fragment of Ste5 allosterically activated autophosphorylation of the mitogen-activated protein kinase Fus3. The resulting form of Fus3 is partially active-it is phosphorylated on only one of two key ...
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ژورنال
عنوان ژورنال: mBio
سال: 2011
ISSN: 2161-2129,2150-7511
DOI: 10.1128/mbio.00230-10